If you need to use one of these drugs with acetaminophen-hydrocodone, the dosage of one or both drugs should be reduced. Taking this medication with drugs that increase the amount of a chemical called serotonin in your body can cause a serious problem.
This problem, called serotonin syndrome, can be fatal. Tell your doctor if you are taking any of these medications:. Taking this medication with drugs that can inhibit activity of certain liver enzymes can increase the amount of hydrocodone in your body and cause more side effects.
You may have increased breathing problems or drowsiness. Examples of these drugs include:. Taking this medication with drugs that can increase activity of certain liver enzymes can lower the amount of hydrocodone or acetaminophen in your body. You may need a higher dose of this medication to control your pain. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions.
Always speak with your healthcare professional about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. Taking it again could be fatal cause death. You should not drink alcohol while taking acetaminophen-hydrocodone. Drinking alcohol while taking this medication may cause:. Suddenly stopping acetaminophen-hydrocodone may cause withdrawal symptoms.
Symptoms of withdrawal from acetaminophen-hydrocodone may include:. Talk with your doctor before stopping acetaminophen-hydrocodone. For people with head injury: If you have a head injury, hydrocodone may cause increased pressure in your brain and cause breathing problems. For people with stomach problems: Use caution taking this drug if you have intestinal obstruction, ulcerative colitis, or constipation. This medication may worsen your symptoms.
For people with severe kidney disease: This drug may build up in your body, which can cause trouble breathing and other side effects.
For people with lung disease: If you have lung disease, you might have trouble breathing if you take this medication. For people with severe liver disease: If you have severe liver disease, your risk of liver failure is increased. Also, this drug may build up in your body, which can cause trouble breathing and other side effects. For people with prostate enlargement: If you have an enlarged prostate, taking acetaminophen-hydrocodone may cause increased difficulty in urination.
For people with asthma: If you have severe or uncontrolled asthma , do not use this medication without talking to your doctor. You may have to take the first few doses in a monitored setting. For people with seizures: If you have epilepsy or have ever had seizures, tell your doctor before taking acetaminophen-hydrocodone. This drug may increase your risk of seizures. For pregnant women: This drug is a category C pregnancy drug. That means two things:. Babies born to mothers who regularly take opioids such as hydrocodone may be born physically dependent on this drug.
This can cause symptoms of withdrawal, or neonatal opioid withdrawal syndrome. Symptoms can include:. For women who are breastfeeding: Acetaminophen is passed in small amounts in breast milk. Hydrocodone also passes into breast milk and may result in excessive tiredness and slowed breathing in a child who is breastfed. Breastfeeding while taking this medication may come with risks.
For seniors: Older adults may have decreased kidney, liver, and heart function. Browse Subject Areas? Click through the PLOS taxonomy to find articles in your field.
Abstract Although opioid-induced nausea and vomiting OINV is common and debilitating, its mechanism is still unclear. Data Availability: All relevant data are within the paper. Introduction Opioids are essential in the treatment of moderate to severe pain [ 1 ], but also induce debilitating nausea and vomiting. Materials and methods Standard protocol approvals, registrations, and patient consent Fourteen healthy men aged Opioid administration Remifentanil, chosen because of its well-known and controllable characteristics, was administered intravenously 0.
Experimental conditions Subjects were divided into two subgroups of equal age Download: PPT. Results Nausea ratings did not differ between the subgroups for each time point T 0 , T 30 , T Discussion Nausea during remifentanil administration was triggered by movement and avoided by rest in all subjects independently of visual input. Acknowledgments We thank Judy Benson for copy-editing the manuscript.
References 1. Porreca F, Ossipov MH Nausea and vomiting side effects with opioid analgesics during treatment of chronic pain: mechanisms, implications, and management options. Pain medicine — Gan TJ Postoperative nausea and vomiting—can it be eliminated? JAMA — Anesthesiology — Curr Med Res Opin — Br J Anaesth 6— Rubin A, Winston J The role of the vestibular apparatus in the production of nausea and vomiting following the administration of morphine to man; clinical and experimental data including the effects of dramamine and benzedrine.
J Clin Invest — J Neurol — Addiction — PLoS One e PLoS One 9: e Carpenter DO, Hori N Neurotransmitter and peptide receptors on medial vestibular nucleus neurons. Ann N Y Acad Sci — Neuroscience — Please note the date of last review or update on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.
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